A wide variety of large numbers crop up in mathematics. Some are contrived, but some actually arise in proofs. Often, it is possible to prove existence theorems by deriving some potentially huge upper limit which is frequently greatly reduced in subsequent versions (e.g., Graham's number, Kolmogorov-Arnold-Moser theorem, Mertens conjecture, Skewes number, Wang's conjecture).
Ackermann number | Barnes G-function | billion | chained arrow notation | circle notation | Eddington number | Erdős-Moser equation | frivolous theorem of arithmetic | gigantic prime | Göbel's sequence | googol | googolplex | Graham's number | hundred | hyperfactorial | jumping champion | Knuth up-arrow notation | law of truly large numbers | mega | megistron | million | monster group | Moser | n-plex | number | power tower | Sierpiński number of the second kind | Skewes number | small number | Steinhaus-Moser notation | strong law of large numbers | sufficiently large | superfactorial | thousand | titanic prime | weak law of large numbers | zillion